Plasmids, which are used in the manufacturing process for vaccines, carry genetic material that can inadvertently enter the human body through vaccination. Plasmids can disrupt cellular functions or contribute to the development of antibiotic resistance. These fragments have the potential to integrate into the DNA of vaccinated individuals, potentially disrupting the function of oncogenes and tumor suppressor genes. One troubling aspect is the inclusion of sequences from the SV40 virus, known for its cancer-causing properties. The implications of such contamination are dire, with experts warning of the potential for permanent genetic changes in vaccine recipients.
This serious safety concern necessitates that ALL recombinant vaccines be investigated for DNA contamination. The current findings on DNA contamination across the vaccine supply are startling, and warrant an audit into the manufacturing processes of vaccines, including investigations into the role adjuvants and lipid nanoparticles play in facilitating the DNA contamination of human cells.
The Port Hedland council in Australia recently passed a motion recognizing "unacceptable levels of plasmid DNA contamination" in mRNA COVID vaccines. The motion, which also mandated the dissemination of this information to health practitioners and vaccine recipients, represents a significant shift in how vaccine safety concerns are addressed. Given Port Hedland's economic significance in Australia, this council's decision is likely to have far-reaching implications. For the first time, health practitioners are being formally alerted to the dangers posed by plasmid contamination -- a topic that has been heavily suppressed since the #plasmidgate controversy surfaced in early 2023.
Compounding the controversy is a recent exposé written by investigative journalist Maryanne Demasi. The exposé reveals similar issues with the Gardasil HPV vaccine. The report highlights the FDA's awareness of residual plasmid DNA in Gardasil, a contamination concern that dates back to 2011. This is an issue that has been blacklisted from vaccine safety discussions in the media and between government regulators.
This DNA contamination is made more dangerous due to the use of adjuvants in vaccines. The adjuvant is added to vaccines to enhance the immune response. One of the most common adjuvants - aluminum salts - technically act as a transfection agent, allowing foreign DNA to enter the cytoplasm of human immune cells, which then circulate throughout the body. The implications of this toxic facilitation are profound; the introduction of lab-derived plasmids into the human body poses significant risks, including the potential for cancer and other genetic diseases.
COVID-19 vaccines use lipid nanoparticles which facilitate the entry of plasmid DNA into human cells. The Novavax vaccine contains a saponin adjuvant that has similar risks as the lipid nanoparticles. A Hepatitis B vaccine (Engerix-B), used in newborn babies, contains both aluminum hydroxide and polysorbate 20. These ingredients act as transfection agents, potentially facilitating plasmids into the baby and setting the stage for childhood cancer.
Moreover, a greater quantity of antigen has a greater chance of introducing plasmids into human cells. Conversely, the DNA contamination could have more pronounced effects on babies with a lower blood volume and body weight. The Engerix vaccine (injected into babies) contains 20 micrograms of antigen, whereas the Gardasil HPV vaccine (injected into teenagers) contains 270 micrograms. The dosage of the antigen is important, as well as the blood volume and weight of the person being injected.
The HPV vaccine contains 13 times more foreign proteins and DNA than the Hep B vaccines. Essentially, the HPV vaccines is equivalent to 13 injections of the Hep vaccine, in terms of antigen quantity. Still, the Hep B vaccine is given to infants, not teenagers, and therefore introduces a disproportionate level of contamination to a baby with lower blood volume and body weight. Both vaccines pose serious DNA contamination risks on two different ends of the exposure spectrum.
Essential to the function of a vaccine is the term "transfection." This process allows foreign genetic material to enter human cells -- a mechanism that typically doesn't occur naturally. Human cells possess protective barriers that prevent the uptake of foreign nucleic acids. However, laboratory techniques have been developed to bypass these defenses. The main methods of transfection include:
Among these, chemical agents are the most viable for introducing nucleic acids into cells. Commonly used transfection agents include cationic particles, which are positively charged and attract the negatively charged components of cell membranes. Detergents can also disrupt membranes, enabling the entry of nucleic acids. The concern surrounding the use of lab-reagent plasmids is significant. These plasmids can contain nucleotides that may lead to severe genetic consequences, including cancer, if transferred into human cells. When a transfection agent is present, the likelihood of this transfer increases substantially.
While many are familiar with standard transfection agents like lipids (lipofectamine, lipid nanoparticles) and calcium phosphate, a broader range of substances can act as transfection agents. Here are some less commonly recognized ones:
Understanding the toxicity potential of these transfection agents is crucial, especially in light of their implications for causing cancer in children, teenagers, and adults.