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The 19-year-old was pronounced deceased at the scene, police said in Monday's statement.
Another driver was taken to hospital with life-threatening injuries and a driver and passenger in a third vehicle were taken to hospital but with injuries that aren't considered life threatening, police said.
Debris and tire tracks were visible Monday in a field on the southwest corner of the intersection and yellow police caution tape was on the ground on the northeast side. Traffic heading north and south on Mandaumin Road is controlled by large stop signs while vehicles heading east and west on Courtright Line continue through the intersection. The speed limit there is 90 kilometres per hour.
Lambton OPP ask anyone in the area at the time who may have witnessed the collision to 1-888-3101122.