(Exact name of Registrant as specified in its charter)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

On October 9, 2024, Can-Fite BioPharma Ltd. issued a press release entitled "FDA Grants Orphan Drug Designation to Can-Fite's Namodenoson for Pancreatic Cancer." A copy of this press release is furnished herewith as Exhibit 99.1.

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.